What if you'd held KPTI?
A $1,000 investment in Karyopharm Therapeutics Inc. (KPTI) at the month-end close of 2013-11 would be worth $7.33 at the close of 2026-09 — -99.3% total return, dividends reinvested. The same $1,000 in the S&P 500, dividends reinvested, would be worth $5,349.
Your scenario
Result
If you'd bought $1,000 at the start of each year
Value of $1,000 invested on January 1 of each year, held to 2026-09, dividends included.
Every year, $1,000 from 2013
| Year | Value of $1,000 | Year return |
|---|---|---|
| 2013 | $1,000 | — |
| 2014 | $1,633 | +63.3% |
| 2015 | $578 | -64.6% |
| 2016 | $410 | -29.1% |
| 2017 | $419 | +2.1% |
| 2018 | $409 | -2.4% |
| 2019 | $836 | +104.6% |
| 2020 | $675 | -19.2% |
| 2021 | $281 | -58.5% |
| 2022 | $148 | -47.1% |
| 2023 | $37.75 | -74.5% |
| 2024 | $29.49 | -21.9% |
| 2025 | $21.41 | -27.4% |
| 2026 | $5.21 | -75.7% |
Best and worst month-end to buy
The best single month-end close to have bought KPTI was 2026-09 ($1.79): $1,000 then is $1,000 today. The worst was 2014-06 ($698): $1,000 then is $2.56.
FAQ
What would $1,000 in KPTI be worth today?
A $1,000 investment in Karyopharm Therapeutics Inc. (KPTI) at the start of 2013 would be worth about $7.33 today, a total return of -99.3%. Dividends are reinvested in these figures.
What were the best and worst years for KPTI?
Karyopharm Therapeutics Inc. (KPTI)'s strongest calendar year since 2013 was 2019, a +104.6% return — $1,000 held through that year became about $2,046 by year-end. Its weakest year was 2026, at -75.7%.
Does the calculator include dividends and splits?
Yes where available. Prices are adjusted for both stock splits and reinvested dividends (total return), the same measure brokerages use.
How much would $100 per month in KPTI have grown?
Investing $100 at the end of every month since 2013-11 would have grown to about $1,184 on $15,500 invested.
Did KPTI beat the S&P 500?
Over the same period, $1,000 in the S&P 500 with dividends reinvested (the S&P 500 Total Return index) would be worth $5,349. KPTI trailed the S&P 500 by +99.9% in total return.
Is this investment advice?
No. Wall Street Regrets is an entertainment and education tool. Every number is a historical calculation, not a prediction, and past performance never guarantees future results.
Methodology
Karyopharm Therapeutics Inc. (KPTI) historical total-return data from 2013-11 to 2026-09, reduced to month-end closes for the tables above.
Returns use adjusted close prices — adjusted for stock splits and reinvested dividends, the same convention used by major brokerages. End-of-day and live prices come from EODHD; parts of the deep historical series are carried over from Yahoo Finance data. A "year" scenario invests $1,000 at the prior December's month-end close and values it at the latest available month-end close. Non-USD amounts are converted at historical month-end exchange rates (EODHD): to USD on the buy date and back to your currency at the latest rate, so the return reflects the currency move as well as the asset.
Month-end resolution means intra-month extremes are not captured in tables; the calculator uses exact trading-day closes where daily data is available. Figures ignore taxes, fees, and the currency effects of non-USD listings. History is not a forecast. Wall Street Regrets is entertainment, not investment advice.
What if you'd held…
Data: adjusted close prices via EODHD and Yahoo Finance. As of 2026-09-04. Not financial advice.