What if you'd held XBI?
A $1,000 investment in State Street SPDR S&P Biotech ETF (XBI) at the month-end close of 2006-02 would be worth $9,780 at the close of 2026-09 — +878.0% total return, dividends reinvested. The same $1,000 in the S&P 500, dividends reinvested, would be worth $8,902.
Your scenario
Result
If you'd bought $1,000 at the start of each year
Value of $1,000 invested on January 1 of each year, held to 2026-09, dividends included.
Every year, $1,000 from 2006
| Year | Value of $1,000 | Year return |
|---|---|---|
| 2006 | $1,000 | — |
| 2007 | $1,290 | +29.0% |
| 2008 | $1,180 | -8.6% |
| 2009 | $1,184 | +0.3% |
| 2010 | $1,392 | +17.6% |
| 2011 | $1,465 | +5.2% |
| 2012 | $1,944 | +32.7% |
| 2013 | $2,884 | +48.4% |
| 2014 | $4,182 | +45.0% |
| 2015 | $4,750 | +13.6% |
| 2016 | $4,016 | -15.5% |
| 2017 | $5,774 | +43.8% |
| 2018 | $4,891 | -15.3% |
| 2019 | $6,484 | +32.6% |
| 2020 | $9,618 | +48.3% |
| 2021 | $7,651 | -20.5% |
| 2022 | $5,673 | -25.9% |
| 2023 | $6,103 | +7.6% |
| 2024 | $6,165 | +1.0% |
| 2025 | $8,378 | +35.9% |
| 2026 | $11,266 | +34.5% |
Best and worst month-end to buy
The best single month-end close to have bought XBI was 2006-05 ($14.16): $1,000 then is $11,569 today. The worst was 2026-09 ($164): $1,000 then is $1,000.
FAQ
What would $1,000 in XBI be worth today?
A $1,000 investment in State Street SPDR S&P Biotech ETF (XBI) at the start of 2006 would be worth about $9,780 today, a total return of +878.0%. Dividends are reinvested in these figures.
What were the best and worst years for XBI?
State Street SPDR S&P Biotech ETF (XBI)'s strongest calendar year since 2006 was 2013, a +48.4% return — $1,000 held through that year became about $1,484 by year-end. Its weakest year was 2022, at -25.9%.
Does the calculator include dividends and splits?
Yes where available. Prices are adjusted for both stock splits and reinvested dividends (total return), the same measure brokerages use.
How much would $100 per month in XBI have grown?
Investing $100 at the end of every month since 2006-02 would have grown to about $110,469 on $24,800 invested.
Did XBI beat the S&P 500?
Over the same period, $1,000 in the S&P 500 with dividends reinvested (the S&P 500 Total Return index) would be worth $8,902. XBI beat the S&P 500 by +9.9% in total return.
Is this investment advice?
No. Wall Street Regrets is an entertainment and education tool. Every number is a historical calculation, not a prediction, and past performance never guarantees future results.
Methodology
State Street SPDR S&P Biotech ETF (XBI) historical total-return data from 2006-02 to 2026-09, reduced to month-end closes for the tables above.
Returns use adjusted close prices — adjusted for stock splits and reinvested dividends, the same convention used by major brokerages. End-of-day and live prices come from EODHD; parts of the deep historical series are carried over from Yahoo Finance data. A "year" scenario invests $1,000 at the prior December's month-end close and values it at the latest available month-end close. Non-USD amounts are converted at historical month-end exchange rates (EODHD): to USD on the buy date and back to your currency at the latest rate, so the return reflects the currency move as well as the asset.
Month-end resolution means intra-month extremes are not captured in tables; the calculator uses exact trading-day closes where daily data is available. Figures ignore taxes, fees, and the currency effects of non-USD listings. History is not a forecast. Wall Street Regrets is entertainment, not investment advice.
What if you'd held…
Data: adjusted close prices via EODHD and Yahoo Finance. As of 2026-09-04. Not financial advice.